Endocrine Abstracts

We have evaluated the effectiveness of radiotherapy in three patients with recurrent symptomatic hypophysitis following surgical decompression.Case 1(54 F); presented with diabetes insipidus, hypopituitarism and a large hypophyseal mass. Following trans-sphenoidal surgery (TSS), a diagnosis of xanthomatous hypophysitis was made. Two years later severe headaches returned, and despite a second trans-sphenoidal procedure, visual acuity further deteriorated in the left eye...

Introduction: Insulinoma is a rare neuroendocrine tumour of the pancreas. Its resection is the only curative treatment. However, medical therapy may be needed to prevent severe preoperative hypoglycaemia, when surgery is contraindicated, delayed or refused and in case of unresectable metastatic disease. To our knowledge, a comparison between these two medications has never been performed.Case report: We describe the case of a 27-year-old patient without ...

Introduction: Many epidemiological studies have shown that people who are small at birth tend to have higher blood pressure latter in life. In this study we evaluated the relation between salt consumption in pregnant rat with birth weight, weight changes during breeding period, weight in third Months and blood pressure.Method: Eight groups, each containing 6 mature rats with 200±20 gr weight were selected, Each group contain 5 non-pregnant rats and ...

Introduction: Salt is an essential compound to provide Na, but over-consumption of salt could be lethal. As using high salt solution is a traditional way of committing suicide in china, In this research, the action of to salt sensation during consumption of salt solution is elevated.Method: 6 groups, each containing 10 male rat with 200 gr weight were selected. 5 concentration of salt in distilled water were prepared (1,3,5,7,9%). During this study, rats...

Background: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is associated with ACTH-driven adrenal androgen excess. In women with classic CAH, this regularly causes prenatal virilisation of the external genitalia, commonly corrected by genital surgery during the first years of life. This practice, however, has been questioned and is discussed highly controversial. The aim of this study was to retrospectively assess the perspective of affected patients and...

Aim: The most common clinical presentation of primary hyperparathyroidism (PHPT) is asymptomatıc and it is diagnosed incidentally without developing complications.In our study, we aimed to examine the characteristics of participants with primary hyperparathyroidism and the relationship between bone mineral density (BMD) and hypercalciuria.Methods: Consecutive 191 normocalciuric (24-h urinary calcium<400 mg/day) patients with PHPT (51±13 yea...

The importance of early detection of diabetes mellitus helps to prevent the development of related chronic complications.Screening, which lasted a week, has been implemented in 31 pharmacies in the territory of the Province of Brindisi (Apulia–Italy) on a random sample of 1048 people. Blood glucose was measured by glucometer; a questionnaire was administered with anthropometric data and medical history and evaluation of the lifestyle of exercise and...

In severe sepsis circulating DHEA sulfate (DHEAS) has been shown to decrease whilst serum cortisol increases. This has led to the suggestion of an intraadrenal shift from adrenal androgen towards glucocorticoid synthesis in severe stress. Patients with sepsis are therefore assumed to be DHEA deficient and have been suggested to benefit from DHEA replacement. However, only desulfated DHEA is biologically active and DHEAS and DHEA may not freely interconvert as previously though...

Background: Impaired glucose (G) regulation (IGR) and diabetes mellitus (DM) are common in patients with liver cirrhosis. DM development has been associated to advanced liver disease (LD) and HCV infection. The relative roles played by insulin secretion and action, advanced LD and HCV infection in DM are somewhat unclear.Aim of the study: To assess in cirrhotic patients candidate to organ transplantation with no history of G abnormalities: i) prevalence ...

BACKGROUND: Male steroidal contraceptive regimens achieve azoospermia in 60-90% of Caucasians. The mechanisms underlying this heterogeneity in response are not clear. The aim of this retrospective study was to examine a number of polymorphisms in genes involved in androgen metabolism and action, in azoospermic responders (n=73) and oligozoospermic non-responders (n=44) from previous contraceptive trials. METHODS: Local Ethical Committee approval was obtained. DNA was extracted...